Target fishing and mechanistic insights of the natural anticancer drug candidate chlorogenic acid

• Main Authors: Qinghua Wang (Author), Tingting Du (Author), Zhihui Zhang (Author), Qingyang Zhang (Author), Jie Zhang (Author), Wenbin Li (Author), Jian-Dong Jiang (Author), Xiaoguang Chen (Author), Hai-Yu Hu (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chlorogenic acid (CGA) is a natural product that effectively inhibits tumor growth, demonstrated in many preclinical models, and phase II clinical trials for patients with glioma. However, its direct proteomic targets and anticancer molecular mechanisms remain unknown. Herein, we developed a novel b...