Urine volume to hydration volume ratio is associated with pharmacokinetics of high‐dose methotrexate in patients with primary central nervous system lymphoma

• Main Authors: Tetsuichiro Isono (Author), Daiki Hira (Author), Aya Morikochi (Author), Tadateru Fukami (Author), Satoshi Ueshima (Author), Kazuhiko Nozaki (Author), Tomohiro Terada (Author), Shin‐ya Morita (Author)
• Format: Book
• Published: Wiley, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract High‐dose methotrexate (HD‐MTX)‐based chemotherapy is the first‐line treatment for primary central nervous system lymphoma (PCNSL), but is associated with severe adverse effects, including myelosuppression and renal impairment. MTX is primarily excreted by the kidneys. Renal function calcul...