MDM2 Is Essential to Maintain the Homeostasis of Epithelial Cells by Targeting p53

• Main Authors: Su Wang (Author), Shufen Zhong (Author), Ying Huang (Author), Songling Zhu (Author), Shuangfeng Chen (Author), Ran Wang (Author), Sonam Wangmo (Author), Bo Peng (Author), Houkun Lv (Author), Jichao Yang (Author), Liyan Ma (Author), Zhiyang Ling (Author), Yaguang Zhang (Author), Pengfei Sui (Author), Bing Sun (Author)
• Format: Book
• Published: Karger Publishers, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: MDM2 is known as the primary negative regulator of p53, and MDM2 promotes lung cancer fibrosis and lung injury through p53-dependent and p53-independent pathways. However, the mechanism by which MDM2 influences the pathogenesis of asthma is unknown. In this study, we investigated the f...