Liver chimeric mice with tupaia hepatocyte transplantation as an animal model for hepatitis B virus infection and antiviral therapy

• Main Authors: Lunzhi Yuan (Author), Yao Chen (Author), Xuan Liu (Author), Yali Zhang (Author), Ming Zhou (Author), Kun Wu (Author), Quan Yuan (Author), Tong Cheng (Author), Ningshao Xia (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The human liver chimeric mouse is a milestone animal model for hepatitis B virus (HBV) infection. Such mice with primary human hepatocyte (PHH) transplantation are adequate to support chronic HBV infection for several weeks and to evaluate antiviral drugs. However, the drawbacks of PHHs include lack...