Synthesis, characterization, preliminary molecular docking, pharmacological activity, and ADME studies of some new pyrazoline derivatives as anti-breast cancer agents

• Päätekijät: Hayder R. Fadhil (Tekijä), Ayad M. R. Raauf (Tekijä), Monther F. Mahdi (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Pensoft Publishers, 2024-09-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

This work studied the anti-breast cancer activities of pyrazoline-containing benzenesulfonamides (6-10) in vitro and silico. The GOLD suite performed molecular docking on the target human estrogen receptor and the PARPA1 antagonist crystal structure, yielding comparable results using tamoxifen as a...