Evaluation of Novel Inhibitors of Tryptophan Dioxygenases for Enzyme and Species Selectivity Using Engineered Tumour Cell Lines Expressing Either Murine or Human IDO1 or TDO2

Evaluation of Novel Inhibitors of Tryptophan Dioxygenases for Enzyme and Species Selectivity Using Engineered Tumour Cell Lines Expressing Either Murine or Human IDO1 or TDO2

Indoleamine 2, 3-dioxygenase 1 (IDO1) is commonly expressed by cancers as a mechanism for evading the immune system. Preclinical and clinical studies have indicated the potential of combining IDO1 inhibitors with immune therapies for the treatment of cancer, strengthening an interest in the discover...

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Main Authors: Sofian M Tijono (Author), Brian D. Palmer (Author), Petr Tomek (Author), Jack U. Flanagan (Author), Kimiora Henare (Author), Swarna Gamage (Author), Lukas Braun (Author), Lai-Ming Ching (Author)
Format: Book
Published: MDPI AG, 2022-08-01T00:00:00Z.
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3rd Floor Main Library

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