Evaluation of Novel Inhibitors of Tryptophan Dioxygenases for Enzyme and Species Selectivity Using Engineered Tumour Cell Lines Expressing Either Murine or Human IDO1 or TDO2

• मुख्य लेखकों: Sofian M Tijono (लेखक), Brian D. Palmer (लेखक), Petr Tomek (लेखक), Jack U. Flanagan (लेखक), Kimiora Henare (लेखक), Swarna Gamage (लेखक), Lukas Braun (लेखक), Lai-Ming Ching (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2022-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Indoleamine 2, 3-dioxygenase 1 (IDO1) is commonly expressed by cancers as a mechanism for evading the immune system. Preclinical and clinical studies have indicated the potential of combining IDO1 inhibitors with immune therapies for the treatment of cancer, strengthening an interest in the discover...