In vitro and in vivo characterization of erythrosin B and derivatives against Zika virus

• Main Authors: Zhong Li (Author), Jimin Xu (Author), Yuekun Lang (Author), Xiangmeng Wu (Author), Saiyang Hu (Author), Subodh Kumar Samrat (Author), Anil M. Tharappel (Author), Lili Kuo (Author), David Butler (Author), Yongcheng Song (Author), Qing-Yu Zhang (Author), Jia Zhou (Author), Hongmin Li (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Zika virus (ZIKV) causes significant human diseases without specific therapy. Previously we found erythrosin B, an FDA-approved food additive, inhibited viral NS2B−NS3 interactions, leading to inhibition of ZIKV infection in cell culture. In this study, we performed pharmacokinetic and in vivo studi...