Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury

• Main Authors: Kranti A. Mapuskar (Author), Casey F. Pulliam (Author), Diana Zepeda-Orozco (Author), Benjamin R. Griffin (Author), Muhammad Furqan (Author), Douglas R. Spitz (Author), Bryan G. Allen (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cisplatin, a potent chemotherapeutic agent, is marred by severe nephrotoxicity that is governed by mechanisms involving oxidative stress, inflammation, and apoptosis pathways. The transcription factor Nrf2, pivotal in cellular defense against oxidative stress and inflammation, is the master regulato...