Neurochemical Changes and c-Fos Mapping in the Brain after Carisbamate Treatment of Rats Subjected to Lithium-Pilocarpine-Induced Status Epilepticus

• Main Authors: José Eduardo Marques-Carneiro (Author), Astrid Nehlig (Author), Jean-Christophe Cassel (Author), Eduardo Ferreira Castro-Neto (Author), Julia Julie Litzahn (Author), Anne Pereira de Vasconcelos (Author), Maria da Graça Naffah-Mazacoratti (Author), Maria José da Silva Fernandes (Author)
• Format: Book
• Published: MDPI AG, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The administration of lithium-pilocarpine (LiPilo) in adult rats is a validated model reproducing the main clinical and neuropathological features of temporal lobe epilepsy (TLE). Previous studies have shown that carisbamate (CRS) has the property of modifying epileptogenesis in this model. When tre...