Expression Kinetics and Innate Immune Response after Electroporation and LNP-Mediated Delivery of a Self-Amplifying mRNA in the Skin

Expression Kinetics and Innate Immune Response after Electroporation and LNP-Mediated Delivery of a Self-Amplifying mRNA in the Skin

In this work, we studied the expression kinetics and innate immune response of a self-amplifying mRNA (sa-RNA) after electroporation and lipid-nanoparticle (LNP)-mediated delivery in the skin of mice. Intradermal electroporation of the sa-RNA resulted in a plateau-shaped expression, with the plateau...

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Main Authors: Hanne Huysmans (Author), Zifu Zhong (Author), Joyca De Temmerman (Author), Barbara L. Mui (Author), Ying K. Tam (Author), Séan Mc Cafferty (Author), Arlieke Gitsels (Author), Daisy Vanrompay (Author), Niek N. Sanders (Author)
Format: Book
Published: Elsevier, 2019-09-01T00:00:00Z.
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