Triarylmethanes, a new class of Cx50 inhibitors

• Main Authors: SILKE eBODENDIEK (Author), CLIO eRUBINOS (Author), MARIA PILAR TRELLES (Author), DAVID eJENKINS (Author), NICHOLE eCOLEMAN (Author), Heike eWulff (Author), MIDUTURU eSRINIVAS (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The paucity of specific pharmacological agents has been a major impediment for delineating the roles of gap junction channels formed by connexin proteins in physiology and pathophysiology. Here, we used the selective optimization of side activities (SOSA) approach, which has led to the design of hig...