Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069.

• المؤلفون الرئيسيون: Melisa Sayé (مؤلف), Lucrecia Gauna (مؤلف), Edward Valera-Vera (مؤلف), Chantal Reigada (مؤلف), Mariana R Miranda (مؤلف), Claudio A Pereira (مؤلف)
• التنسيق: كتاب
• منشور في: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

<h4>Background</h4>Crystal violet (CV) was used for several years in blood banks to eliminate the parasite Trypanosoma cruzi in endemic areas in order to prevent transfusion-transmitted Chagas disease. One mechanism of action described for CV involves inhibition of proline uptake. In T....