Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069.

• প্রধান লেখক: Melisa Sayé (লেখক), Lucrecia Gauna (লেখক), Edward Valera-Vera (লেখক), Chantal Reigada (লেখক), Mariana R Miranda (লেখক), Claudio A Pereira (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

<h4>Background</h4>Crystal violet (CV) was used for several years in blood banks to eliminate the parasite Trypanosoma cruzi in endemic areas in order to prevent transfusion-transmitted Chagas disease. One mechanism of action described for CV involves inhibition of proline uptake. In T....