Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069.

• Main Authors: Melisa Sayé (Author), Lucrecia Gauna (Author), Edward Valera-Vera (Author), Chantal Reigada (Author), Mariana R Miranda (Author), Claudio A Pereira (Author)
• Format: Bog
• Udgivet: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

<h4>Background</h4>Crystal violet (CV) was used for several years in blood banks to eliminate the parasite Trypanosoma cruzi in endemic areas in order to prevent transfusion-transmitted Chagas disease. One mechanism of action described for CV involves inhibition of proline uptake. In T....