Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069.

• Κύριοι συγγραφείς: Melisa Sayé (Συγγραφέας), Lucrecia Gauna (Συγγραφέας), Edward Valera-Vera (Συγγραφέας), Chantal Reigada (Συγγραφέας), Mariana R Miranda (Συγγραφέας), Claudio A Pereira (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

<h4>Background</h4>Crystal violet (CV) was used for several years in blood banks to eliminate the parasite Trypanosoma cruzi in endemic areas in order to prevent transfusion-transmitted Chagas disease. One mechanism of action described for CV involves inhibition of proline uptake. In T....