Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069.

• Egile Nagusiak: Melisa Sayé (Egilea), Lucrecia Gauna (Egilea), Edward Valera-Vera (Egilea), Chantal Reigada (Egilea), Mariana R Miranda (Egilea), Claudio A Pereira (Egilea)
• Formatua: Liburua
• Argitaratua: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

<h4>Background</h4>Crystal violet (CV) was used for several years in blood banks to eliminate the parasite Trypanosoma cruzi in endemic areas in order to prevent transfusion-transmitted Chagas disease. One mechanism of action described for CV involves inhibition of proline uptake. In T....