Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069.

• Päätekijät: Melisa Sayé (Tekijä), Lucrecia Gauna (Tekijä), Edward Valera-Vera (Tekijä), Chantal Reigada (Tekijä), Mariana R Miranda (Tekijä), Claudio A Pereira (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

<h4>Background</h4>Crystal violet (CV) was used for several years in blood banks to eliminate the parasite Trypanosoma cruzi in endemic areas in order to prevent transfusion-transmitted Chagas disease. One mechanism of action described for CV involves inhibition of proline uptake. In T....