Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069.

• Príomhchruthaitheoirí: Melisa Sayé (Údar), Lucrecia Gauna (Údar), Edward Valera-Vera (Údar), Chantal Reigada (Údar), Mariana R Miranda (Údar), Claudio A Pereira (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

<h4>Background</h4>Crystal violet (CV) was used for several years in blood banks to eliminate the parasite Trypanosoma cruzi in endemic areas in order to prevent transfusion-transmitted Chagas disease. One mechanism of action described for CV involves inhibition of proline uptake. In T....