Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069.

• Autori principali: Melisa Sayé (Autore), Lucrecia Gauna (Autore), Edward Valera-Vera (Autore), Chantal Reigada (Autore), Mariana R Miranda (Autore), Claudio A Pereira (Autore)
• Natura: Libro
• Pubblicazione: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

<h4>Background</h4>Crystal violet (CV) was used for several years in blood banks to eliminate the parasite Trypanosoma cruzi in endemic areas in order to prevent transfusion-transmitted Chagas disease. One mechanism of action described for CV involves inhibition of proline uptake. In T....