Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069.

• 主要な著者: Melisa Sayé (著者), Lucrecia Gauna (著者), Edward Valera-Vera (著者), Chantal Reigada (著者), Mariana R Miranda (著者), Claudio A Pereira (著者)
• フォーマット: 図書
• 出版事項: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

<h4>Background</h4>Crystal violet (CV) was used for several years in blood banks to eliminate the parasite Trypanosoma cruzi in endemic areas in order to prevent transfusion-transmitted Chagas disease. One mechanism of action described for CV involves inhibition of proline uptake. In T....