Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069.

• Үндсэн зохиолчид: Melisa Sayé (Зохиогч), Lucrecia Gauna (Зохиогч), Edward Valera-Vera (Зохиогч), Chantal Reigada (Зохиогч), Mariana R Miranda (Зохиогч), Claudio A Pereira (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

<h4>Background</h4>Crystal violet (CV) was used for several years in blood banks to eliminate the parasite Trypanosoma cruzi in endemic areas in order to prevent transfusion-transmitted Chagas disease. One mechanism of action described for CV involves inhibition of proline uptake. In T....