Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069.

• Hoofdauteurs: Melisa Sayé (Auteur), Lucrecia Gauna (Auteur), Edward Valera-Vera (Auteur), Chantal Reigada (Auteur), Mariana R Miranda (Auteur), Claudio A Pereira (Auteur)
• Formaat: Boek
• Gepubliceerd in: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

<h4>Background</h4>Crystal violet (CV) was used for several years in blood banks to eliminate the parasite Trypanosoma cruzi in endemic areas in order to prevent transfusion-transmitted Chagas disease. One mechanism of action described for CV involves inhibition of proline uptake. In T....