Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069.

• Principais autores: Melisa Sayé (Autor), Lucrecia Gauna (Autor), Edward Valera-Vera (Autor), Chantal Reigada (Autor), Mariana R Miranda (Autor), Claudio A Pereira (Autor)
• Formato: Livro
• Publicado em: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

<h4>Background</h4>Crystal violet (CV) was used for several years in blood banks to eliminate the parasite Trypanosoma cruzi in endemic areas in order to prevent transfusion-transmitted Chagas disease. One mechanism of action described for CV involves inhibition of proline uptake. In T....