Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069.

• Главные авторы: Melisa Sayé (Автор), Lucrecia Gauna (Автор), Edward Valera-Vera (Автор), Chantal Reigada (Автор), Mariana R Miranda (Автор), Claudio A Pereira (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• Предметы: article
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<h4>Background</h4>Crystal violet (CV) was used for several years in blood banks to eliminate the parasite Trypanosoma cruzi in endemic areas in order to prevent transfusion-transmitted Chagas disease. One mechanism of action described for CV involves inhibition of proline uptake. In T....