Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069.

• Váldodahkkit: Melisa Sayé (Dahkki), Lucrecia Gauna (Dahkki), Edward Valera-Vera (Dahkki), Chantal Reigada (Dahkki), Mariana R Miranda (Dahkki), Claudio A Pereira (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

<h4>Background</h4>Crystal violet (CV) was used for several years in blood banks to eliminate the parasite Trypanosoma cruzi in endemic areas in order to prevent transfusion-transmitted Chagas disease. One mechanism of action described for CV involves inhibition of proline uptake. In T....