Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069.

• Asıl Yazarlar: Melisa Sayé (Yazar), Lucrecia Gauna (Yazar), Edward Valera-Vera (Yazar), Chantal Reigada (Yazar), Mariana R Miranda (Yazar), Claudio A Pereira (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

<h4>Background</h4>Crystal violet (CV) was used for several years in blood banks to eliminate the parasite Trypanosoma cruzi in endemic areas in order to prevent transfusion-transmitted Chagas disease. One mechanism of action described for CV involves inhibition of proline uptake. In T....