Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069.

• Những tác giả chính: Melisa Sayé (Tác giả), Lucrecia Gauna (Tác giả), Edward Valera-Vera (Tác giả), Chantal Reigada (Tác giả), Mariana R Miranda (Tác giả), Claudio A Pereira (Tác giả)
• Định dạng: Sách
• Được phát hành: Public Library of Science (PLoS), 2020-01-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

<h4>Background</h4>Crystal violet (CV) was used for several years in blood banks to eliminate the parasite Trypanosoma cruzi in endemic areas in order to prevent transfusion-transmitted Chagas disease. One mechanism of action described for CV involves inhibition of proline uptake. In T....