Differential effects of metformin‐mediated BSEP repression on pravastatin and bile acid pharmacokinetics in humans: A randomized controlled trial

• Main Authors: Melissa Metry (Author), Samuel A. Krug (Author), Vijaya Kumari Karra (Author), Maureen A. Kane (Author), Jeffrey C. Fink (Author), Yan Shu (Author), Hongbing Wang (Author), James E. Polli (Author)
• Format: Book
• Published: Wiley, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Metformin has been shown to repress transcription of the bile salt export pump (BSEP) in human primary hepatocytes. The primary objective of this study was to assess the effect of oral metformin on the human pharmacokinetics (PKs) of two BSEP probe substrates: pravastatin and chenodeoxychol...