miR-133a Promotes TRAIL Resistance in Glioblastoma via Suppressing Death Receptor 5 and Activating NF-κB Signaling

• Main Authors: Shan-shan Wang (Author), Lu Feng (Author), Bao-guang Hu (Author), Ying-fei Lu (Author), Wei-mao Wang (Author), Wei Guo (Author), Chun-wai Suen (Author), Bao-hua Jiao (Author), Jian-xin Pang (Author), Wei-ming Fu (Author), Jin-fang Zhang (Author)
• Format: Book
• Published: Elsevier, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recombinant tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), as a novel cancer therapeutic, is being tested in phase II and III clinical trials; however, TRAIL resistance remains a big obstacle preventing its clinical application. Considering that TRAIL-induced apoptosis throug...