Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity

• Main Authors: Grant Generaux (Author), Vinal V. Lakhani (Author), Yuching Yang (Author), Sashi Nadanaciva (Author), Luping Qiu (Author), Keith Riccardi (Author), Li Di (Author), Brett A. Howell (Author), Scott Q. Siler (Author), Paul B. Watkins (Author), Hugh A. Barton (Author), Michael D. Aleo (Author), Lisl K. M. Shoda (Author)
• Format: Book
• Published: Wiley, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Many compounds that appear promising in preclinical species, fail in human clinical trials due to safety concerns. The FDA has strongly encouraged the application of modeling in drug development to improve product safety. This study illustrates how DILIsym, a computational representation of...