Microbubble drug conjugate and focused ultrasound blood brain barrier delivery of AAV-2 SIRT-3

• Main Authors: Dennison Trinh (Author), Joanne Nash (Author), David Goertz (Author), Kullervo Hynynen (Author), Sharshi Bulner (Author), Umar Iqbal (Author), James Keenan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background Delivery of viral vectors as gene therapies to treat neurodegenerative diseases has been hampered by the inability to penetrate the blood brain barrier (BBB) and invasive or non-targeted delivery options prone to inducing immune responses. MR guided focused ultrasound (MR-g-FUS) and micro...