Endothelial phosphodiesterase 4B inactivation ameliorates endothelial-to-mesenchymal transition and pulmonary hypertension

• Main Authors: Yanjiang Xing (Author), Yangfeng Hou (Author), Tianfei Fan (Author), Ran Gao (Author), Xiaohang Feng (Author), Bolun Li (Author), Junling Pang (Author), Wenjun Guo (Author), Ting Shu (Author), Jinqiu Li (Author), Jie Yang (Author), Qilong Mao (Author), Ya Luo (Author), Xianmei Qi (Author), Peiran Yang (Author), Chaoyang Liang (Author), Hongmei Zhao (Author), Wenhui Chen (Author), Jing Wang (Author), Chen Wang (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pulmonary hypertension (PH) is a fatal disorder characterized by pulmonary vascular remodeling and obstruction. The phosphodiesterase 4 (PDE4) family hydrolyzes cyclic AMP (cAMP) and is comprised of four subtypes (PDE4A-D). Previous studies have shown the beneficial effects of pan-PDE4 inhibitors in...