Reposition of the anti-inflammatory drug diacerein in an in-vivo colorectal cancer model

• Main Authors: Raghda T. Abdel-Latif (Author), Walaa Wadie (Author), Yousra Abdel-mottaleb (Author), Dalaal M. Abdallah (Author), Nabila N. El-Maraghy (Author), Hanan S. El-Abhar (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Excessive interleukin (IL)-6 production is a driver for malignancy and drug resistance in colorectal cancer (CRC). Our study investigated a seven-week post-treatment with the anti-inflammatory drug, Diacerein (Diac), alone or in combination with 5-fluorouracil (5-FU), using a 1,2-dimethylhydrazine (...