Ritonavir-Mediated Induction of Apoptosis in Pancreatic Cancer Occurs via the RB/E2F-1 and AKT Pathways

• Main Authors: Ramesh B. Batchu (Author), Oksana V. Gruzdyn (Author), Christopher S. Bryant (Author), Aamer M. Qazi (Author), Sanjeev Kumar (Author), Sreedhar Chamala (Author), Shu T. Kung (Author), Ramana S. Sanka (Author), Udaya S. Puttagunta (Author), Donald W. Weaver (Author), Scott A. Gruber (Author)
• Format: Book
• Published: MDPI AG, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent observations suggest a lower incidence of malignancies in patients infected with HIV during treatment with Highly Active Anti-Retroviral Therapy (HAART) utilizing protease inhibitors. We investigated the effects of ritonavir, a FDA approved HIV protease inhibitor, on proliferation of pancreat...