LC-MS/MS Method for the Quantification of PARP Inhibitors Olaparib, Rucaparib and Niraparib in Human Plasma and Dried Blood Spot: Development, Validation and Clinical Validation for Therapeutic Drug Monitoring

• Main Authors: Giovanni Canil (Author), Marco Orleni (Author), Bianca Posocco (Author), Sara Gagno (Author), Alessia Bignucolo (Author), Marcella Montico (Author), Rossana Roncato (Author), Serena Corsetti (Author), Michele Bartoletti (Author), Giuseppe Toffoli (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Poly (ADP-ribose) polymerase inhibitors (PARPis) are becoming increasingly meaningful in oncology, and their therapeutic drug monitoring (TDM) might be beneficial for patients. Several bioanalytical methods have been reported for PARPis quantification in human plasma, but advantages might be obtaine...