Repurposed drugs as histone deacetylase 8 inhibitors: Implications in cancer and neuropathological conditions

• Main Authors: Mohammed Alrouji (Author), Kumar Venkatesan (Author), Mohammed S. Alshammari (Author), Fahad A. Alhumaydhi (Author), Sheeba Shafi (Author), Sharaf E. Sharaf (Author), Moyad Shahwan (Author), Anas Shamsi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Histone deacetylase 8 (HDAC8) is a member of class I histone deacetylases (HDACs) that catalyzes the deacetylation of both histone and non-histone proteins. Dysregulation and overexpression of HDAC8 are implicated in the development of various complex diseases, including cancer and neurodegenerative...