Chronic hyperinsulinemia promotes human hepatocyte senescence

• Main Authors: Ritesh K. Baboota (Author), Rosa Spinelli (Author), Malin C. Erlandsson (Author), Bruna B. Brandao (Author), Marsel Lino (Author), Hong Yang (Author), Adil Mardinoglu (Author), Maria I. Bokarewa (Author), Jeremie Boucher (Author), C. Ronald Kahn (Author), Ulf Smith (Author)
• Format: Book
• Published: Elsevier, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Cellular senescence, an irreversible proliferative cell arrest, is caused by excessive intracellular or extracellular stress/damage. Increased senescent cells have been identified in multiple tissues in different metabolic and other aging-related diseases. Recently, several human and mous...