The Promising Role of Chitosan-Poloxamer 188 Nanocrystals in Improving Diosmin Dissolution and Therapeutic Efficacy against Ferrous Sulfate-Induced Hepatic Injury in Rats

• Main Authors: Neamet S. Lotfy (Author), Thanaa M. Borg (Author), Elham A. Mohamed (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2021-12-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Diosmin (DSN) exhibits poor water solubility and low bioavailability. Although nanocrystals (NCs) are successful for improving drug solubility, they may undergo crystal growth. Therefore, DSN NCs were prepared, employing sonoprecipitation utilizing different stabilizers. The optimum stabilizer was c...