Post-Translational Modifications of p53 in Ferroptosis: Novel Pharmacological Targets for Cancer Therapy

• Egile Nagusiak: Le Zhang (Egilea), Ningning Hou (Egilea), Bing Chen (Egilea), Chengxia Kan (Egilea), Fang Han (Egilea), Jingwen Zhang (Egilea), Xiaodong Sun (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The tumor suppressor p53 is a well-known cellular guardian of genomic integrity that blocks cell cycle progression or induces apoptosis upon exposure to cellular stresses. However, it is unclear how the remaining activities of p53 are regulated after the abrogation of these routine activities. Ferro...