Osthole Attenuates Macrophage Activation in Experimental Asthma by Inhibitingthe NF-ĸB/MIF Signaling Pathway

• Main Authors: Ruyi Li (Author), Peng Song (Author), Guofang Tang (Author), Jianghong Wei (Author), Lizong Rao (Author), Libing Ma (Author), Ming Jiang (Author), Jianwei Huang (Author), Qing Xu (Author), Jingjie Wu (Author), Qian Lv (Author), Dong Yao (Author), Bo Xiao (Author), Haiming Huang (Author), Liping Lei (Author), Juntao Feng (Author), Biwen Mo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibition of activated macrophages is an alternative therapeutic strategy for asthma. We investigated whether a coumarin compound, osthole, isolated from Cnidiummonnieri (L.) Cuss, alleviated macrophage activation in vivo and in vitro. Osthole could reduce expression of a marker of activated macrop...