Norcantharidin Sensitizes Colorectal Cancer Cells to Radiotherapy via Reactive Oxygen Species-DRP1-Mediated Mitochondrial Damage

• मुख्य लेखकों: Qiong Xu (लेखक), Heng Zhang (लेखक), Haoren Qin (लेखक), Huaqing Wang (लेखक), Hui Wang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2024-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Norcantharidin (NCTD), a cantharidin derivative, induces ROS generation and is widely used to treat CRC. In this study, we clarified the role and mechanism of action of norcantharidin in increasing CRC sensitivity to radiotherapy. We treated the CRC cell lines LoVo and DLD-1 with NCTD (10 or 50 μmol...