Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling

• Main Authors: Qin Tang (Author), Yong Gao (Author), Qinhui Liu (Author), Xuping Yang (Author), Tong Wu (Author), Cuiyuan Huang (Author), Ya Huang (Author), Jinhang Zhang (Author), Zijing Zhang (Author), Rui Li (Author), Shiyun Pu (Author), Guorong Zhang (Author), Yingnan Zhao (Author), Jian Zhou (Author), Hui Huang (Author), Yanping Li (Author), Wei Jiang (Author), Yongsheng Chang (Author), Jinhan He (Author)
• Format: Book
• Published: Elsevier, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Sirt6 is an essential regulator of energy metabolism in multiple peripheral tissues. However, the direct role of Sirt6 in the hypothalamus, specifically pro-opiomelanocortin (POMC) neurons, controlling energy balance has not been established. Here, we aimed to determine the role of Sirt6...