Preclinical Toxicity and Safety of MM-129-First-in-Class BTK/PD-L1 Inhibitor as a Potential Candidate against Colon Cancer

MM-129 is a novel inhibitor targeting BTK/PI3K/AKT/mTOR and PD-L1, as it possesses antitumor activity against colon cancer. To evaluate the safety profile of MM-129, we conducted a toxicity study using the zebrafish and rodent model. MM-129 was also assessed for pharmacokinetics features through an...

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Main Authors: Justyna Magdalena Hermanowicz (Author), Bartlomiej Kalaska (Author), Krystyna Pawlak (Author), Beata Sieklucka (Author), Joanna Miklosz (Author), Mariusz Mojzych (Author), Dariusz Pawlak (Author)
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出版: MDPI AG, 2021-08-01T00:00:00Z.
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索引号: A1234.567
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