Cover Image

Evaluation of 5-[(<i>Z</i>)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone (Les-6222) as Potential Anticonvulsant Agent

It was determined that the studied 5-[(<i>Z</i>)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone (Les-6222) affects the cyclooxygenase pathway of the arachidonic acid cascade, the markers of damage to neurons on models of PTZ kindling. In the model of chronic epileptogenesis...

Full description

Saved in:

Bibliographic Details
Main Authors:	Mariia Mishchenko (Author), Sergiy Shtrygol' (Author), Andrii Lozynskyi (Author), Mykhailo Hoidyk (Author), Dmytro Khyluk (Author), Tatyana Gorbach (Author), Roman Lesyk (Author)
Format:	Book
Published:	MDPI AG, 2022-09-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Thiazole-Bearing 4-Thiazolidinones as New Anticonvulsant Agents
by: Mariia Mishchenko, et al.
Published: (2020)

Evaluation of Anticonvulsant Activity of Dual COX-2/5-LOX Inhibitor Darbufelon and Its Novel Analogues
by: Mariia Mishchenko, et al.
Published: (2021)

Synthesis and Biological Activity Evaluation of Novel 5-Methyl-7-phenyl-3<i>H</i>-thiazolo[4,5-<i>b</i>]pyridin-2-ones
by: Andrii Lozynskyi, et al.
Published: (2021)

Biodistribution and Anticancer Characteristics of Les-3833, A Novel 4-thiazolidinone-Based Lead Compound
by: Lesya Kobylinska, et al.
Published: (2020)

Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry
by: Anna Kryshchyshyn, et al.
Published: (2018)

Research on the pharmacological potential of 1-alkyl derivatives of 3,5-dimethyl-4-((4-nitrobenzylidene)amino)-1,2,4-triazolium bromide
by: O. I. Panasenko, et al.
Published: (2024)

Synthesis, antioxidant activity, and density functional theory study of some novel 4-[(benzo[d]thiazol-2-ylimino)methyl]phenol derivatives: a comparative approach for the explanation of their radical scavenging activities
by: Mohammad hossein Asgarshamsi, et al.
Published: (2021)

A New 4-Thiazolidinone Derivative (Les-6490) as a Gut Microbiota Modulator: Antimicrobial and Prebiotic Perspectives
by: Yulian Konechnyi, et al.
Published: (2024)

Novel Thiazole-Fused [4,5-<i>g</i>] or [5,4-<i>g</i>]Quinazolin-8-ones and Their Quinazoline Analogues: Synthesis and Biological Evaluation
by: Nathan Broudic, et al.
Published: (2024)

Synthesis and preliminary antimicrobial evaluation of new 7-amino-4-methyl-coumarin thiazolidinone conjugates
by: Muthanna S. Farhan, et al.
Published: (2024)

5-Benzyliden-2-(5-methylthiazol-2-ylimino)thiazolidin-4-ones as Antimicrobial Agents. Design, Synthesis, Biological Evaluation and Molecular Docking Studies
by: Michelyne Haroun, et al.
Published: (2021)

Synthesis, Characterization and Acute Anti-inflammatory Evaluation of New Mefenamic Acid Derivatives Having 4-Thiazolidinone Nucleus
by: Mustafa Hussein al, et al.
Published: (2019)

Synthesis, Characterization and Acute Anti-inflammatory Evaluation of New Mefenamic Acid Derivatives Having 4-Thiazolidinone Nucleus
by: Mustafa H. Ali Alsafi, et al.
Published: (2019)

Design, Synthesis, Characterization, Biological Activity and ADME Study of New 5-arylidene-4-Thiazolidinones Derivatives Having
by: Duha E. Taha, et al.
Published: (2019)

(Hetero)aryl substituted thiazol-2,4-yl scaffold as human carbonic anhydrase I, II, VII and XIV activators
by: Marouan Rami, et al.
Published: (2019)

4-(Indol-3-yl)thiazole-2-amines and 4-ιndol-3-yl)thiazole Acylamines as Νovel Antimicrobial Agents: Synthesis, In Silico and In Vitro Evaluation
by: Sergei Simakov, et al.
Published: (2021)

3-[5-(1<i>H</i>-Indol-3-ylmethylene)-4-oxo-2-thioxothiazolidin-3-yl]-propionic Acid as a Potential Polypharmacological Agent
by: Yulian Konechnyi, et al.
Published: (2023)

Design, Synthesis, and Acute Anti-inflammatory Assessment of New 2-methyl Benzoimidazole Derivatives Having 4-Thiazolidinone Nucleus
by: Abdul Muhaimen Amjed Adnan, et al.
Published: (2019)

Synthesis, Characterization and Antimicrobial Evaluation with DFT Study of New Two-Amino-4-(4-Chlorophenyl) Thiazole Derivatives
by: Ammar A Mahmood Kubba, et al.
Published: (2018)

The study of antiexudative action of S-alkylated 1,3,4-oxadiazole-3-thionе derivatives
by: Yu. L. Shepeta, et al.
Published: (2019)

The psycho- and neurotropic profiling of novel 3-(N-R,R'-aminomethyl)-2-methyl-1H-quinolin-4-ones in vivo
by: Illya M. Podolsky, et al.
Published: (2018)

Novel Thiazolidine-2,4-dione-trimethoxybenzene-thiazole Hybrids as Human Topoisomerases Inhibitors
by: Maria Stefania Sinicropi, et al.
Published: (2023)

Neurolocomotor Behavior and Oxidative Stress Markers of Thiazole and Thiazolidinedione Derivatives against <i>Nauphoeta cinerea</i>
by: Pedro Silvino Pereira, et al.
Published: (2022)

Design and Microwave Synthesis of New (5<i>Z</i>) 5-Arylidene-2-thioxo-1,3-thiazolinidin-4-one and (5<i>Z</i>) 2-Amino-5-arylidene-1,3-thiazol-4(5<i>H</i>)-one as New Inhibitors of Protein Kinase DYRK1A
by: Khadidja Bourahla, et al.
Published: (2021)

New pyrazolyl-thiazolidinone/thiazole derivatives as celecoxib/dasatinib analogues with selective COX-2, HER-2 and EGFR inhibitory effects: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis, molecular modelling and ADME studies
by: Wael A. A. Fadaly, et al.
Published: (2023)

The synthesis of N-(4-aryl-thiazol-2-yl)-N1-(4,5,6,7-tetrahydro-3H-azepin-2-yl)-hydrazine hydrobromides and the cardioprotective activity of (41-methoxyphenyl-thiazol-2-yl) derivative
by: Sergii А. Demchenko, et al.
Published: (2021)

Synthesis and Identification of Complexes of [1, 2-diphenyl -2- (pyrazin -2- ylimino)- ethanone oxime] with Some Metal Salts
by: A.N. Al-Jeboori, et al.
Published: (2009)

Modification of 4-(4-chlorothiophen-2-yl)thiazol-2-amine derivatives for the treatment of analgesia and inflammation: synthesis and in vitro, in vivo, and in silico studies
by: Mater H. Mahnashi, et al.
Published: (2024)

The memory and learning enhancing effects of Atristamine
by: Illya Podolsky, et al.
Published: (2019)

Anticonvulsant activity 2-((5-(3-(4-fluorophenyl)-4-R2-1,2,4-triazole-3-yl)-thio)-1-arylethanone
by: O. A. Bihdan
Published: (2019)

Molecular docking, ADMET study and in vivo pharmacological research of N-(3,4-dimetoxyphenyl)-2-{[2-methyl-6-(pyridine-2-yl)-pyrimidin-4-yl]thio}acetamide as a promising anticonvulsant
by: Hanna I. Severina, et al.
Published: (2020)

Synthesis of New Thiazole Derivatives Bearing Thiazolidin-4(5H)-One Structure and Evaluation of Their Antimicrobial Activity
by: Asaf Evrim Evren, et al.
Published: (2022)

Synthesis and cytotoxicity evaluation of some new 6-nitro derivatives of thiazole-containing 4-(3H)-quinazolinone
by: Leila Hosseinzadeh, et al.
Published: (2016)

Synthesis of novel 5-substituted 2-pyrazolylthiazol-4-ones as potential bioligically active compounds
by: I. M. Yushyn, et al.
Published: (2020)

Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights
by: Al-Warhi T, et al.
Published: (2022)

Discovery of novel conjugates of quinoline and thiazolidinone urea as potential anti-colorectal cancer agent
by: Li Xiong, et al.
Published: (2022)

Exploring Kinase Inhibition Properties of 9<i>H</i>-pyrimido[5,4-<i>b</i>]- and [4,5-<i>b</i>]indol-4-amine Derivatives
by: Yvonnick Loidreau, et al.
Published: (2020)

Discovery of new thymol-3,4-disubstituted thiazole hybrids as dual COX-2/5-LOX inhibitors with in vivo proof
by: Mostafa M. M. El-Miligy, et al.
Published: (2024)

Design, Synthesis and In Vitro Antimicrobial Activity of 6-(1<i>H</i>-Benzimidazol-2-yl)-3,5-dimethyl-4-oxo-2-thio-3,4-dihydrothieno[2,3-<i>d</i>]pyrimidines
by: Sergiy V. Vlasov, et al.
Published: (2021)

Synthesis and biological evaluation of anti-Toxoplasma gondii activity of a novel scaffold of thiazolidinone derivatives
by: Simone Carradori, et al.
Published: (2017)