Evaluation of 5-[(<i>Z</i>)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone (Les-6222) as Potential Anticonvulsant Agent

• Príomhchruthaitheoirí: Mariia Mishchenko (Údar), Sergiy Shtrygol' (Údar), Andrii Lozynskyi (Údar), Mykhailo Hoidyk (Údar), Dmytro Khyluk (Údar), Tatyana Gorbach (Údar), Roman Lesyk (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: MDPI AG, 2022-09-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

It was determined that the studied 5-[(<i>Z</i>)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone (Les-6222) affects the cyclooxygenase pathway of the arachidonic acid cascade, the markers of damage to neurons on models of PTZ kindling. In the model of chronic epileptogenesis...