Evaluation of 5-[(<i>Z</i>)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone (Les-6222) as Potential Anticonvulsant Agent

• Main Authors: Mariia Mishchenko (Author), Sergiy Shtrygol' (Author), Andrii Lozynskyi (Author), Mykhailo Hoidyk (Author), Dmytro Khyluk (Author), Tatyana Gorbach (Author), Roman Lesyk (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

It was determined that the studied 5-[(<i>Z</i>)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone (Les-6222) affects the cyclooxygenase pathway of the arachidonic acid cascade, the markers of damage to neurons on models of PTZ kindling. In the model of chronic epileptogenesis...