Agomelatine-based in situ gels for brain targeting via the nasal route: statistical optimization, in vitro, and in vivo evaluation

• Principais autores: Ahmed M. Fatouh (Autor), Ahmed H. Elshafeey (Autor), Ahmed Abdelbary (Autor)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Agomelatine (AGM) is an antidepressant drug with a low absolute bioavailability due to the hepatic first pass metabolism. AGM-loaded solid lipid nanoparticles were formulated in the form of an in situ gel to prolong the intranasal retention time and subsequently to increase the absorbed amount of AG...