Differential expression and function of PDE8 and PDE4 in effector T cells: Implications for PDE8 as a drug target in inflammation.

• Main Authors: Amanda G. Vang (Author), Hongli Dong (Author), Rebecca K. Nguyen (Author), Chaitali Basole (Author), William Housley (Author), Linda Guernsey (Author), Alexander J Adami (Author), Roger Thrall (Author), Robert Bennett Clark (Author), Paul Mark Epstein (Author), Stefan Brocke (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abolishing the inhibitory signal of intracellular cAMP is a prerequisite for effector T (Teff) cell function. The regulation of cAMP within leukocytes critically depends on its degradation by cyclic nucleotide phosphodiesterases (PDEs). We have previously shown that PDE8A, a PDE isoform with 40-100-...