Chronic depletion of vertebrate lipids in Aedes aegypti cells dysregulates lipid metabolism and inhibits innate immunity without altering dengue infectivity.

• Main Authors: Andrew D Marten (Author), Clara T Tift (Author), Maya O Tree (Author), Jesse Bakke (Author), Michael J Conway (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aedes aegypti is the primary vector of dengue virus (DENV) and other arboviruses. Previous literature suggests that vertebrate and invertebrate lipids and the nutritional status of mosquitoes modify virus infection. Here, we developed a vertebrate lipid-depleted Ae. aegypti cell line to investigate...